Not all carbapenem-resistant Pseudomonas aeruginosa strains are alike: tailoring antibiotic therapy based on resistance mechanisms
SUMMARY
Antimicrobial resistance in Pseudomonas aeruginosa remains a serious health threat because multiple mechanisms may be involved that further complicate the management of infections.
A recent article published in Current Opinion in Infectious Diseases expresses the importance of understanding the diverse resistance mechanisms in carbapenem-resistant P. aeruginosa including enzymatic degradation, changes in permeability, and efflux pump overexpression. The authors stress the importance of understanding local epidemiology and resistance patterns to guide empirical therapy, while advocating for targeted antibiotic selection based on susceptibility testing. With several new antipseudomonal agents available, the article provides crucial insights into rational antibiotic use to combat resistant P. aeruginosa strains while preserving future treatment options.
FEATURED EXPERTS
Marco Falcone, MD, Infectious Diseases Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy
Valentina Galfo, MD, Infectious Diseases Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy
Giusy Tiseo, MD, Infectious Diseases Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italya
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Explore critical insights into combating antibiotic resistance in Pseudomonas aeruginosa.
PUBLISHED BY
January 08, 2025
